Monday, April 29, 2013

Mirren, Rylance up for London's Olivier awards

FILE- British actress Helen Mirren in London, for the United Kingdom Premiere of 'The Debt', in this file photo dated Wednesday, Sept. 21, 2011. Mirren is widely seen as a favorite to reign as best actress for her performance as Queen Elizabeth II in "The Audience", when the winners are announced later Sunday April 28, 2013, at London's Olivier theatre awards.(AP Photo/Joel Ryan, File)

FILE- British actress Helen Mirren in London, for the United Kingdom Premiere of 'The Debt', in this file photo dated Wednesday, Sept. 21, 2011. Mirren is widely seen as a favorite to reign as best actress for her performance as Queen Elizabeth II in "The Audience", when the winners are announced later Sunday April 28, 2013, at London's Olivier theatre awards.(AP Photo/Joel Ryan, File)

(AP) ? Helen Mirren is a favorite to reign at London's Olivier theater awards Sunday for her performance as Queen Elizabeth II in "The Audience."

Mirren is a best-actress nominee for the awards, the British equivalent of Broadway's Tonys.

She stars in Peter Morgan's play about the private weekly meetings between the monarch and Britain's prime ministers over the six decades of her reign. Mirren is no stranger to royalty ? she won an Academy award in 2007 for the same role in "The Queen."

She's up against Hattie Morahan for "A Doll's House," Billie Piper for "The Effect" and Kristin Scott Thomas for "Old Times."

Male acting nominees are Rupert Everett for Oscar Wilde drama "The Judas Kiss"; James McAvoy for "Macbeth"; Mark Rylance for a cross-dressing turn in "Twelfth Night"; Rafe Spall for the relationship drama "Constellations"; and Luke Treadaway for "The Curious Incident of the Dog in the Night-Time."

The National Theatre's acclaimed production of "Curious Incident" ? based on Mark Haddon's novel about a mystery-solving boy with Asperger's syndrome ? leads the race with eight nominations, while the jaunty musical "Top Hat" has seven.

Nominees for musicals include Michael Ball and Imelda Staunton for "Sweeney Todd," Alex Bourne and Hannah Waddingham for "Kiss Me, Kate" and Heather Headley for "The Bodyguard."

Two political dramas ?"The Audience" and rough-and-tumble Parliamentary saga "This House" ? are up for best new play, alongside the love story "Constellations" and "The Curious Incident of the Dog in the Night-Time."

The best new musical nominees are the geeks-made-good story "Loserville"; the Tina Turner tribute "Soul Sister"; the movie-inspired "The Bodyguard"; and the high-stepping "Top Hat."

Winners in most categories are chosen by a panel of theater professionals and members of the public. Nominees for the Audience Award, decided by public vote, are "Billy Elliot"; "Matilda: The Musical"; "The Phantom of the Opera"; and "Wicked."

The winners will be announced during a ceremony at the Royal Opera House in London hosted by stage star Sheridan Smith and "Downton Abbey" actor Hugh Bonneville.

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Jill Lawless can be reached at http://Twitter.com/JillLawless

Online: http://www.olivierawards.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-28-Britain-Theater%20Awards/id-67da04ab912446ad988d9c29cbafd686

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Sunday, April 28, 2013

FAA: Air traffic system soon at full operation

A United Airlines jet departs in view of the air traffic control tower at Seattle-Tacoma International Airport Tuesday, April 23, 2013, in Seattle. A day after flight delays plagued much of the U.S., air travel is smoother Tuesday. But the government is warning passengers that the situation can change by the hour as it runs the nation's air traffic control system with a smaller staff. Airlines and members of Congress urged the Federal Aviation Administration to find other ways to make mandatory budget cuts besides furloughing controllers. While delays haven't been terrible yet, the airlines are worried about the long-term impact late flights will have on their budgets and on fliers. (AP Photo/Elaine Thompson)

A United Airlines jet departs in view of the air traffic control tower at Seattle-Tacoma International Airport Tuesday, April 23, 2013, in Seattle. A day after flight delays plagued much of the U.S., air travel is smoother Tuesday. But the government is warning passengers that the situation can change by the hour as it runs the nation's air traffic control system with a smaller staff. Airlines and members of Congress urged the Federal Aviation Administration to find other ways to make mandatory budget cuts besides furloughing controllers. While delays haven't been terrible yet, the airlines are worried about the long-term impact late flights will have on their budgets and on fliers. (AP Photo/Elaine Thompson)

The control tower stands in the background as a passenger lays on the pavement outside the international terminal at Hartsfield-Jackson airport, Friday, April 26, 2013, in Atlanta. Congress easily approved legislation Friday ending furloughs of air traffic controllers that have delayed hundreds of flights daily, infuriating travelers and causing political headaches for lawmakers.(AP Photo/David Goldman)

A passenger sits at right in the international terminal at Hartsfield-Jackson airport, Friday, April 26, 2013, in Atlanta. Congress easily approved legislation Friday ending furloughs of air traffic controllers that have delayed hundreds of flights daily, infuriating travelers and causing political headaches for lawmakers.(AP Photo/David Goldman)

The control tower stands in the background as a passenger paces while on the phone outside the international terminal at Hartsfield-Jackson airport, Friday, April 26, 2013, in Atlanta. Congress easily approved legislation Friday ending furloughs of air traffic controllers that have delayed hundreds of flights daily, infuriating travelers and causing political headaches for lawmakers.(AP Photo/David Goldman)

NEW YORK (AP) ? The Federal Aviation Administration said that the U.S. air traffic system will resume normal operations by Sunday evening after lawmakers rushed a bill through Congress allowing the agency to withdraw furloughs of air traffic controllers and other workers.

The FAA said Saturday that it has suspended all employee furloughs and that traffic facilities will begin returning to regular staffing levels over the next 24 hours. The furloughs were fallout from the $85 billion in automatic-across-the-board spending cuts this spring. The bill, passed on Friday, allows the FAA to move as much as $253 million within its budget to areas that will allow it to prevent reduced operations and staffing.

The furloughs started to hit air traffic controllers this past week, causing flight delays that left thousands of travelers frustrated and furious. Planes were forced to take off and land less frequently, so as not to overload the remaining controllers on duty.

The FAA had no choice but to cut $637 million as its share of $85 billion in automatic, government-wide spending cuts that must be achieved by the end of the federal budget year on Sept. 30.

Flight delays piled up across the country Sunday and Monday of this week as the FAA kept planes on the ground because there weren't enough controllers to monitor busy air corridors. Cascading delays held up flights at some of nation's busiest airports, including New York, Baltimore and Washington. Delta Air Lines canceled about 90 flights Monday because of worries about delays. Just about every passenger was rebooked on another Delta flight within a couple of hours. Air travel was smoother Tuesday.

Things could have been worse. A lot of people who had planned to fly this week changed their plans when they heard that air travel might be difficult, according to longtime aviation consultant Daniel Kasper of Compass Lexicon.

"Essentially what happened from an airline's perspective is that people who were going to travel didn't travel," he said. But canceled flights likely led to lost revenue for airlines. Even if they didn't have to incur some of costs of fueling up planes and getting them off the ground, crews that were already scheduled to work still had to paid.

"One week isn't going to kill them, but had it gone on much longer, it would have been a significant hit on their revenues and profits," Kasper said.

It's also a toll on travelers. At New York's LaGuardia airport on Friday, traveler Roger Bentley said "getting on a flight and being delayed really puts people on the spot. It puts people on the edge and makes people edgy and that's not something I want."

The challenges this week probably cost airlines less than disruptions from a typical winter storm, said John F. Thomas, an aviation consultant with L.E.K. Consulting.

"I think the fact that it got resolved this week has minimized the cost as it was more the inconvenience factor," Thomas said.

The budget cuts at the FAA were required under a law enacted two years ago as the government was approaching its debt limit. Democrats were in favor of raising the debt limit without strings attached so as not to provoke an economic crisis, but Republicans insisted on substantial cuts in exchange. The compromise was to require that every government "program, project and activity" ? with some exceptions, like Medicare ? be cut equally.

The FAA had reduced the work schedules of nearly all of its 47,000 employees by one day every two weeks, including 15,000 air traffic controllers, as well as thousands of air traffic supervisors, managers and technicians who keep airport towers and radar facility equipment working. That amounted to a 10 percent cut in hours and pay.

Republicans accused the Obama administration of forcing the furloughs to raise public pressure on Congress to roll back the budget cuts. Critics of the FAA insist the agency could have reduce its budget in other ways that would not have inconvenience travelers including diverting money from other accounts, such as those devoted to research, commercial space transportation and modernization of the air traffic control computers.

President Barack Obama chided lawmakers Saturday over their fix for widespread flight delays, deeming it an irresponsible way to govern, dubbing it a "Band-Aid" and a quick fix, rather than a lasting solution to the spending cuts known as the sequester.

"Republicans claimed victory when the sequester first took effect, and now they've decided it was a bad idea all along," Obama said, singling out the GOP even though the bill passed with overwhelming Democratic support in both chambers.

He scolded lawmakers for helping the Federal Aviation Administration while doing nothing to replace other cuts that he said harm federal employees, unemployed workers and preschoolers in Head Start.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-27-FAA-Furloughs/id-8a9330e37a0a400392cdb0d139da10b4

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Are there more abortion doctors like Kermit Gosnell? And do we want to know? (Washington Post)

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Saturday, April 13, 2013

How Alzheimer's could occur

Apr. 11, 2013 ? A new hypothesis has been developed by researchers in Bochum on how Alzheimer's disease could occur. They analysed the interaction of the proteins FE65 and BLM that regulate cell division. In the cell culture model, they discovered spherical structures in the nucleus that contained FE65 and BLM. The interaction of the proteins triggered a wrong signal for cell division. This may explain the degeneration and death of nerve cells in Alzheimer's patients.

The team led by Dr. Thorsten M?ller and Prof. Dr. Katrin Marcus from the Department of Functional Proteomics in cooperation with the RUB's Medical Proteome Centre headed by Prof. Helmut E. Meyer reported on the results in the Journal of Cell Science.

Components of spherical structures in the nucleus identified

The so-called amyloid precursor protein APP is central to Alzheimer's disease. It spans the cell membrane, and its cleavage products are linked to protein deposits that form in Alzheimer patients outside the nerve cells. APP anchors the protein FE65 to the membrane, which was the focus of the current study. FE65 can migrate into the nucleus, where it plays a role in DNA replication and repair. Based on cells grown in the laboratory, the team led by Dr. M?ller established that FE65 can unite with other proteins in the cell nucleus to form spherical structures, so-called "nuclear spheres." Video microscopy showed that these ring-like structures merge with each other and can thus grow. "By using a special cell culture model, we were able to identify additional components of these spheres," says Andreas Schr?tter, PhD student in the working group Morbus Alzheimer at the Institute for Functional Proteomics. Among other things, the scientists found the protein BLM, which is known from Bloom's syndrome -- an extremely rare hereditary disease, which is associated with dwarfism, immunodeficiency, and an increased risk of cancer. BLM is involved in DNA replication and repair in the nucleus.

The amount of FE65 determines the amount of BLM in the cell nucleus

M?ller's team took a closer look at the function of FE65. By means of genetic manipulation, the researchers generated cell cultures, in which the FE65-production was reduced. A smaller amount of FE65 thus generated a smaller amount of the protein BLM in the nucleus. Instead, BLM collected in another area of the cell, the endoplasmic reticulum. In addition, the researchers found a lower rate of DNA replication in the genetically modified cells. In this way, FE65 influences the replication of the genetic material via the BLM protein. When the researchers cranked up the FE65-production again, the amount of BLM in the nucleus also increased again.

FE65 as a possible trigger for Alzheimer's

In patients with Alzheimer's disease, the protein APP, an interaction partner of FE65, changes. The interaction of the two molecules is important for the transport of FE65 into the nucleus, where it regulates cell division in combination with BLM. M?ller's team assumes that the altered APP-FE65 interaction mistakenly sends the cells the signal to divide. Since nerve cells normally cannot divide, they degenerate instead and die. "This hypothesis, which we pursue in the working group Morbus Alzheimer, also delivers new starting points for potential therapies, which are urgently needed for Alzheimer's disease," says Dr. Mueller. In the future, the team will also investigate whether and how the amount of BLM is altered in Alzheimer's patients compared to healthy subjects.

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The above story is reprinted from materials provided by Ruhr-Universitaet-Bochum, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A. Schrotter, T. Mastalski, F. M. Nensa, M. Neumann, C. Loosse, K. Pfeiffer, F. E. Magraoui, H. W. Platta, R. Erdmann, C. Theiss, J. Uszkoreit, M. Eisenacher, H. E. Meyer, K. Marcus, T. Muller. FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease. Journal of Cell Science, 2013; DOI: 10.1242/jcs.121004

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/dZC8n7VbTdQ/130411123618.htm

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10 Things to See: A week of top AP photos

Members of Egypt's April 6 Youth Movement shout anti-Muslim Brotherhood slogans and light flares during a rally in front of the prosecutor general's office in Cairo, Egypt, Saturday, April 6, 2013. Thousands of activists took to the streets Saturday to mark the fifth anniversary of the founding of a leading opposition group, the April 6 Youth Movement, and to push a long list of demands on Morsi, including the formation of a more inclusive government amid a worsening economy.(AP Photo/Amr Nabil)

Members of Egypt's April 6 Youth Movement shout anti-Muslim Brotherhood slogans and light flares during a rally in front of the prosecutor general's office in Cairo, Egypt, Saturday, April 6, 2013. Thousands of activists took to the streets Saturday to mark the fifth anniversary of the founding of a leading opposition group, the April 6 Youth Movement, and to push a long list of demands on Morsi, including the formation of a more inclusive government amid a worsening economy.(AP Photo/Amr Nabil)

Michigan guard Trey Burke (3) shoots over Louisville center Gorgui Dieng (10) during the second half of the NCAA Final Four tournament college basketball championship game Monday, April 8, 2013, in Atlanta. (AP Photo/Charlie Neibergall)

This citizen journalism image taken on Sunday, April 7, 2013 provided by Aleppo Media Center AMC which has been authenticated based on its contents and other AP reporting, shows Syrian citizens searching for bodies in the rubble of damaged buildings that were attacked by Syrian forces airstrikes, in the al-Ansari neighborhood of Aleppo, Syria. More than 70,000 people have died since Syria's crisis erupted in March 2011. The Syria-based Violations Documentation Center says nearly 9,000 government troops have been killed in two years of fighting between President Bashar Assad's forces and rebels trying to topple him. (AP Photo/Aleppo Media Center AMC)

Copies of President Barack Obama's budget plan for fiscal year 2014 are distributed to Senate staff on Capitol Hill in Washington, Wednesday, April 10, 2013. The president sent Congress a $3.77 trillion spending blueprint that seeks to tame runaway deficits by raising taxes further on the wealthy and trimming popular benefit programs but has drawn angry responses from both the right and left. (AP Photo/J. Scott Applewhite)

Amish girls play softball after class during an end of the school year celebration on Tuesday, April 9, 2013 in Bergholz, Ohio. The celebration was also part of a farewell picnic for those sentenced in the hair and beard cutting scandal earlier in the year. (AP Photo/Scott R. Galvin)

Here's your look at highlights from the weekly AP photo report, a gallery featuring a mix of front-page photography, the odd image you might have missed and lasting moments our editors think you should see.

This week's collection includes a youth demonstration against the Muslim Brotherhood in Egypt, Amish girls celebrating the end of school with a softball game, Madonna in Malawi and a highlight from the final game of the NCAA basketball tournament.

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This gallery contains images published April 4-11, 2013.

Follow AP photographers on Twitter: http://apne.ws/VyAhxg

___

See other recent AP photo galleries:

Portraits from an immigration rally: http://apne.ws/ZbuQ91

Poverty's grip as seen in Baltimore: http://apne.ws/Yfa1Gy

The NCAA title game in photos: http://apne.ws/Yf8z6U

Scenes from the NCAA final four: http://apne.ws/10O9E7p

6-year-olds chase their ballet dreams: http://apne.ws/Zjf6Og

King Assassination 45 Years Later: http://apne.ws/YoW9hs

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AP10ThingsToSee Week 1: http://apne.ws/ZWiCOl

AP10ThingsToSee Week 2: http://apne.ws/ZWiJt0

AP10ThingsToSee Week 3: http://apne.ws/10USsze

AP10ThingsToSee Week 4: http://apne.ws/14Qg5N1

AP10ThingsToSee Week 5: http://apne.ws/ZbwW8U

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Follow AP Images on Twitter: https://twitter.com/AP_Images

Visit AP Images online: http://www.apimages.com

___

This gallery was curated by news producer Barbara Whitaker in New York: http://apne.ws/Zjq868

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-11-10%20Things%20To%20See/id-07e9f146ae6a44e6890f691342d04a18

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Friday, April 12, 2013

How to Create Random Numbers Using Radioactive Material

Think of a random number between one and ten. Most likely, you chose seven—so exactly how random was your choice? Turns out that generating a truly random number is more difficult than you might think—but this video should help you get to grips with the problem. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/y9S5zHByf8o/how-to-create-random-numbers-using-radioactive-material

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New way to clear cholesterol from the blood

Apr. 10, 2013 ? Researchers at the University of Michigan have identified a new potential therapeutic target for lowering cholesterol that could be an alternative or complementary therapy to statins.

Scientists in the lab of David Ginsburg at the Life Sciences Institute inhibited the action of a gene responsible for transporting a protein that interferes with the ability of the liver to remove cholesterol from the blood in mice. Trapping the destructive protein where it couldn't harm receptors responsible for removing cholesterol preserved the liver cells' capacity to clear plasma cholesterol from the blood, but did not appear to otherwise affect the health of the mice.

In the research, published April 9 in the online journal eLife, scientists found that mice with an inactive SEC24A gene could develop normally. However, their plasma cholesterol levels were reduced by 45 percent because vesicles from liver cells were not able to recruit and transport a critical regulator of blood cholesterol levels called proprotein convertase subtilisin/kexin type 9. PCSK9 is a secretory protein that destroys the liver cells' receptors of low-density lipoprotein- LDL, the so-called "bad cholesterol" -- and prevents the cells from removing the LDL.

"Inhibiting SEC24A or PCSK9 may be an alternative to statins, and could work together with statins to produce even greater effects," said Xiao-Wei Chen of the Ginsburg lab, the first author on the paper. "Also, they might be effective on patients who are resistant to or intolerant of statins."

Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically and work with statins like Lipitor to lower it even further. The Ginsburg lab's research points to a new area for study: rather than inhibiting PCSK9 itself, perhaps future therapies could block the transport mechanism that allows the destructive protein to reach the LDL receptors.

The paper, "SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion," explains the mechanism by which cells transport PCSK9. Vesicles transport proteins in the cell; the Ginsburg lab's research focused on a specialized type of vesicle packaged by the Coat Protein Complex II, which regulates the metabolism of cholesterol, among many other things. These vesicles selectively transport cargo proteins including PCSK9.

Without those LDL receptors (LDLR), liver cells are not able to remove LDLs from the bloodstream, so protecting the LDLR from PCSK9 would allow the receptors to continue to remove cholesterol.

"Without SEC24A, much of the PCSK9 couldn't make its way out of the cells to destroy the LDLR, which then clears cholesterol from the blood," Chen said.

The part of the vesicle that selects which proteins to transport is SEC24. By blocking SEC24A gene, the researchers disabled the vesicle's selection of PCSK9. The destructive protein remained trapped within the cells, leaving the LDLR intact and enabling the liver to clear the body of cholesterol that otherwise could accumulate in arteries.

"We have no reason at this point to expect that this strategy will be any better than anti-PCSK9 therapy for treating high cholesterol, but it would be another alternative approach, and it's hard to predict which drugs will work the best and be the safest until we actually try them out in people," Ginsburg said.

Ginsburg is a research professor at the Life Sciences Institute, where his laboratory is located. He is also the James V. Neel Distinguished University Professor and the Warner-Lambert/Parke-Davis Professor in the Division of Molecular Medicine and Genetics, Department of Internal Medicine and departments of Human Genetics and Pediatrics at the U-M Medical School and a Howard Hughes Medical Institute Investigator.

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Story Source:

The above story is reprinted from materials provided by University of Michigan.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. X.-W. Chen, H. Wang, K. Bajaj, P. Zhang, Z.-X. Meng, D. Ma, Y. Bai, H.-H. Liu, E. Adams, A. Baines, G. Yu, M. A. Sartor, B. Zhang, Z. Yi, J. Lin, S. G. Young, R. Schekman, D. Ginsburg. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. eLife, 2013; 2 (0): e00444 DOI: 10.7554/eLife.00444

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/aOwne_jUt2w/130410141535.htm

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